Paul Giamatti is to take over the role of Larry in the upcoming Three Stooges film originally set to be played by Sean Penn. The Farrelly Brothers, who are directing the film, had Benicio Del Toro and Penn attached as Moe and Larry respectively with Jim Carrey linked to the role of Curly. Giamatti's varied resume includes
Sideways,
Fred Clause and the brilliant
American Splendor where he played everyday cynic Harvey Pekar the creator of the autobiographical comic book of the same name as the film.

Giamatti as Harvey Pekar
The Farrellys have said that the new film will not be biographical or a remake but instead new Three Stooges episodes set in the present day. The plot of the episodes is said to be an adventure that revolves around the Stooges characters.The film taken to MGM studios will start production later this year and is set to be released in 2010.
In the small list of brotherly filmmaking partnerships The Farrelly brothers are definitely somewhere near the bottom, with the Coens undoubtedly topping. However they do have their merits and are probably well suited to making a stooges movie due to their expertise in slapstick.

Source- Dark horizons