Remember Mr White? He got shot in the leg at the end of
Casino Royale? He got vaguely threatened with torture in
Quantum of Solace? No? This guy:

Well, chances are Jesper Christensen, the actor in the role, will not be returning to the series. At the Berlin Film Festival, Christensen said that he is happy that his "interlude as a villain in the James Bond series is over."
What does this mean for Bond's quest against the Quantum organisation? The original ending for
Quantum of Solace featured Mr White and Guy Haines being confronted by Bond, so it's quite likely that this will feature in the next film.
When ased why he was glad not to do any more Bond films, Christensen stated, "Today, I admit that I regard [Casino Royale] and [Quantum of Solace] as really shit. All the people die in them, so two movies are enough for me.
A man after my own heart. With no certain release date for the next Bond flick, and no knowledge of the future of MGM Studios, it will be a fair few years before we find out what impact - if any - this will have on Bond.
Source:
http://www.mi6.co.uk/news/index.php?itemid=8330